Endoplasmic Reticulum Stress in Disease Pathogenesis
نویسندگان
چکیده
منابع مشابه
Endoplasmic reticulum stress and fungal pathogenesis converge
EditoriaL EditoriaL The endoplasmic reticulum (ER) forms an elaborate membra-nous network that functions as the major processing center for the folding and assembly of secreted and membrane proteins. Several environmental conditions can overwhelm the protein folding capacity of the ER, resulting in the accumulation of unfolded proteins. Since unfolded proteins can seed the formation of protein ...
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Synthesis of transmembrane and secretory proteins occurs within the endoplasmic reticulum (ER) and is extremely important in the normal functioning of both the heart and kidney. The dysregulation of protein synthesis/processing within the ER causes the accumulation of unfolded proteins, thereby leading to ER stress and the activation of the unfolded protein response. Sarcoplasmic reticulum/ER C...
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ژورنال
عنوان ژورنال: Annual Review of Pathology: Mechanisms of Disease
سال: 2008
ISSN: 1553-4006,1553-4014
DOI: 10.1146/annurev.pathmechdis.3.121806.151434